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The affected gene networks span tissue remodeling, antioxidant defense, anti-inflammatory pathways, DNA repair, ubiquitin-proteasome function, and nervous system signaling
Clinically, this points to a bi-directional interaction between gut inflammation and brain inflammation, with mast cells acting as key transducers in both arenas 24
Individuals noticing initial thinning within the past five years, particularly affecting the crown region, match the clinical profile most responsive to treatment
Bibcode:1990FEBSL.267..189A
Epub 2018 Sep 17
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