Retatrutide, on the other hand, is a newer investigational agent described as a triple-agonist (targeting GLP-1, GIP, and glucagon receptors) and has demonstrated promising early data for greater weight reduction and fat-burning potential
Regulatory Outlook and Potential NHS Availability Retatrutide has not been submitted for regulatory approval in the UK
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Tirzepatide, a newer medication, combines GLP-1 and GIP receptor agonists, which have a more potent effect on weight loss, with research showing it may lead to greater reductions in body weight compared to Semaglutide
A phase 2 trial (SYNERGY-NASH) first demonstrated in vivo that GLP-1RA can achieve histological reversal of hepatic fibrosis in MASLD