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The glucagon receptor activation (paradoxically) adds metabolic benefits when paired with GLP-1 and GIP , such as promoting energy expenditure and fat oxidation, possibly combating the decrease in basal metabolic rate that accompanies weight loss, and helping reduce liver fat

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[6] [5] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

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