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No significant differences were observed across metabotypes in TMAO AUC change between placebo and pomegranate interventions (Supplementary Figure 3), but mean TMAO AUC values differed between metabotypes following pomegranate intervention (Supplementary Figure 4)

That approach improves interpretability, reduces unnecessary escalation, and keeps the work anchored in a research-only context where safety controls and documentation are part of the protocol, not an afterthought

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