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Conformational changes in PDI alter its compact conformation and expose the normally shielded hydrophobic regions, which regulates its chaperone activity (Wang et al., 2012, 2015)

SotgiaSPaliogiannisPSotgiuEMellinoSZinelluEFoisAGet alSystematic review and meta-analysis of the blood glutathione redox state in chronic obstructive pulmonary disease

Neurological examination revealed disorientation, ocular abnormalities, weakness, sensory deficits, and preserved ankle jerks

Either way, those things can cause the number on the scale to go up, not down

"It is important to note that the situation is essentially unchanged," Nichols said