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Several adipokines with effects on insulin action, energy metabolism or appetite control have been studied, but none has succeeded beyond initial clinical trials (ESM Appendix 3)

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Sometimes a deficiency causes neurological symptoms, such as numbness in the hands and feet, confusion, or trouble speaking or walking

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In TME, the inhibition of LDHA also restricts cells with glycolysis as a preferential metabolic mode, such as Tregs, MDSCs and TAMs, which ultimately hinders the progression of tumours