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On the 12mg maintenance dose, participants lost an average of 28.7% of body weight versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)

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Diuretics may increase the risk of dehydration, especially in patients with persistent vomiting and diarrhea

However, GLP-1 possesses broader pharmacological effects including anti-inflammation, neuro-protection, regulating blood pressure (BP), and reducing lipotoxicity

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