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In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase
On the one hand, ethanol or acetaldehyde promotes ferritin degradation and free iron release via NCOA4-mediated ferritinophagy, contributing to ferroptosis
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Patients should: Continue Zepbound at the current dose Add glucose monitoring 4 times daily during the course Watch for symptoms of hyperglycemia (excessive thirst, frequent urination, blurred vision, fatigue) Loop in their provider if fasting glucose stays above 180 mg/dL for 3 consecutive days Long courses (over 30 days)
