Clinically, SIRS includes respiratory symptoms, ranging in severity from mild tachypnea to respiratory failure, persistent pulmonary hypertension, irritability, lethargy, temperature instability, poor perfusion and hypotension, disseminated intravascular coagulation, poor feeding, vomiting and ileus
Additionally, optimizing dosing schedules and timing in combination regimens can maximize therapeutic efficacy while minimizing toxicity to normal tissues
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(PubMed) Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y
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