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We found that dietary gossypol (GOS) induced a significant increase of FFAs in liver, resulting in lipotoxicity in Nile tilapia compared to control

This process begins with the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, followed by further oxidation to 5-formylcytosine and 5-carboxylcytosine, with the oxidized intermediates eventually removed through the base excision repair mechanism, restoring the DNA to an unmethylated state

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Without adequate methylation processes the individual cannot adapt or heal effectively and will suffer the delirious effects of accelerated aging (5)

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