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10.1021/acsinfecdis.0c00288 8
Brand name Active drug Indication Approval year Max approved dose Ozempic Semaglutide Type 2 diabetes (glycemic control) 2017 2 mg/week Wegovy Semaglutide Chronic weight management (BMI 30 or 27 + comorbidity) 2021 2.4 mg/week Rybelsus Semaglutide Type 2 diabetes (oral daily tablet) 2019 14 mg/day (oral) Mounjaro Tirzepatide Type 2 diabetes (glycemic control) 2022 15 mg/week Zepbound Tirzepatide Chronic weight management (BMI 30 or 27 + comorbidity) 2023 15 mg/week Table 1 FDA-approved indications for semaglutide and tirzepatide brand names
However, they work through different mechanisms to activate AMPK
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The bottom line Since the earliest days of GLP-1s with exenatide in 2005, through the past two decades to Ozempic and Mounjaro, the field has come a long way and will continue to evolve
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