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CNS Spectr 30(1): e23
Dosing is identical regardless of sex
385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage
The demyelinating process is accompanied, amongst other factors, by extensive neuroinflammation (Gold et al., 2006)
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