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As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system

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Intravenous glutathione bypasses absorption barriers and is used clinically at doses of 6002400 mg per administration, often once or twice weekly

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doi:10.1097/gme.0b013e3181b8e02d

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