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As required by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) 12,13,14,15 , and to extend the safety evaluation in a broader population with T2D, the tirzepatide clinical development program for treatment of T2D (SURPASS) was also designed to evaluate the drugs cardiovascular safety in people with T2D at low, medium and high cardiovascular risk 12

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However, one study of severely underweight women with anorexia found that carnitine supplements did not raise levels of this amino acid in the blood nor did it improve muscle weakness

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