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Pramlintide is not appropriate for patients with: Gastroparesis or other conditions causing delayed gastric emptying, as the drug's mechanism of action could worsen this Hypoglycaemia unawareness, due to the risk of compounding insulin-related hypoglycaemia Poor adherence to insulin therapy or self-monitoring of blood glucose In the UK context, NICE guidelines for type 1 diabetes (NG17) and type 2 diabetes (NG28) do not include pramlintide within their recommended treatment pathways

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Lower levels of the A1 proinflammatory form of astrocytes were seen following administration of NLY01 [73]