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In the synovial fluid of individuals with OA, increased lactate facilitates lactylation of UDP-glucose dehydrogenase (UGDH) at lysine 6, disrupting its interaction with signal transducer and activator of transcription 1 (STAT1), suppressing its enzymatic activity and glycosaminoglycan synthesis, and altering its nuclear-cytoplasmic distribution, activating the MAPK signaling pathway and ultimately contributing to OA progression

(2021) 17:e1009503

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This research work was financially supported by C-CC

Discard the vial if the solution becomes cloudy, discolored, or develops visible particles