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Shin DM, Walsh GL, Smythe WR, Ro JY, Shin HJ, Swisher SG , Lu C, Fossella FV, Khuri FR, Yalamanchilli A, Hong WK, Khokhar A, Perez-Solar R

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A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism