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While initiation of motor neuron degeneration appears cell-intrinsic, other cell types including astrocytes, microglia, and T-lymphocytes are key components in the disease progression of ALS, and cell transplantation could more effectively be targeted at replacing these cell types rather than motor neurons

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Found in high concentrations in heart and liver tissues, L-Carnitine facilitates the transport of fatty acids into the mitochondria, where they are converted into energy (ATP)