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Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig
Otherwise, PG is a precursor substance for GLP-1, which is enzymatically cleaved to GLP-1 by prohormone convertase 1 in intestinal L cells 20
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Medication interactions: Use caution if taking anticoagulants, thyroid medication, or drugs for chronic conditions
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