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Ex-4 also promotes brain-derived insulin production and enhances insulin signaling through the Wnt/-catenin/NeuroD1 signaling pathway, which subsequently reduces tau hyperphosphorylation and cognitive dysfunction in diabetic mice [64]

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The Lens Opacities Case-Control Study Group

We found an indirect effect of GLP-1RAs on SA through BMI(OR 0.86 [95%CI 0.751.00], P = 4.56 10 2 ), with a mediation proportion of 20.28% (95% CI [0.3740.16%]),and through current tobacco smoking (OR 0.95 [95%CI 0.910.99], P = 2.75 10 2 ), with a mediation proportion of 6.65% (95%CI [0.74%12.57%]).The mediating effect of alcohol consumption was not observed (P = 1.29 10 1 ) (Fig