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But for some people, the nausea was severe enough that they dropped out of the trial entirely
However, there are important exceptions
Even so-called "miracle drugs" have trade-offs
B12 acts as a cofactor for two important enzymes: methionine synthase, which is involved in DNA production and methylation processes, and methylmalonyl-CoA mutase, which is essential for fatty acid metabolism and energy production
Fletcher JM, Morton CJ, Zwar RA, Murray SS, OLeary PD, Hughes RA (2008) Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor
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