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It is widely involved in regulating vasodilation ( 2 S are strictly concentration-dependent, acting as a double-edged sword: at physiological levels it functions as a beneficial signaling molecule, whereas at high concentrations it becomes strongly cytotoxic by inhibiting cytochrome c oxidase (Complex IV) at the end of the mitochondrial respiratory chain, leading to energy depletion ( 2 S in health and disease extremely complex, requiring the body to maintain H 2 S within a narrow steady-state window via a sophisticated metabolic regulatory system ( In the H 2 S metabolic regulatory network, sulfide:quinone oxidoreductase (SQOR) is a crucial rate-limiting enzyme ( 2 S to chemically more stable persulfides, the first and irreversible step of the sulfide oxidation pathway

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The effects became measurable after 20 weeks of treatment, providing objective biochemical confirmation of what patients reported experiencing

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