Why This Matters for Side Effects Gastrointestinal side effects such as nausea, vomiting, and diarrhea are common with both oral and injectable GLP-1 medications, occurring at rates similar across formulations and generally described as mild to moderate. Starting at lower doses and titrating carefully, as Whoosh's protocols are designed to do, is one of the most effective ways to minimize these effects while still achieving meaningful weight loss
124 Moreover, many peptide drugs are not known to be substrates or inhibitors of transporters at present, indicating that transporter-mediated biliary or renal excretion may not be a major pathway for their elimination
In a large-scale study involving 560 overweight and obese adults, the efficacy of GLP-1 Formula was demonstrated over a multi-week trial period
No direct causal link has been established between GLP-1R use and increased aspiration risk
That said, more studies need to be conducted before we draw any firm conclusions [12][13]