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In the CNS, ammonia is theorized to cause inflammation, oxidative injury, astrocyte swelling, increased NMDA activity, and osmotic stress which can all lead to brain injury and cerebral edema

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A network meta-analysis published in the Journal of the Endocrine Society found retatrutide achieved 23.77% weight reduction compared to 16.79% for tirzepatide when standardized across trials, with absolute weight loss of 16.34 kg versus 11.82 kg

6 McKay, N.J., S.E