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Persistently low B12 levels can cause pernicious anemia, stomach problems or nerve damage

That observation became the foundation for one of the most extensively cited copper-peptide research lines in tissue-biology literature, and its the reason GHK-Cu is still classified in research today as an endogenous signaling peptide rather than a synthetic compound designed from scratch

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It represents a significant shift from gut-hormone-based treatments, operating entirely within the central nervous system