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Treatment induces p53-pS15 nuclear exclusion, triggering the apoptotic cascade specifically in senescent fibroblasts while sparing healthy cells
ISBN 0-553-26322-6
Nat Commun 16 , 5672 (2025)
As hinted above, this predicament could be disentangled via studies that include a mechanistic assessment of biomarkers predicting response versus harm following GLP-1RA administration 192
In terms of specifics, the main finding was that about 28% of patients on ixekizumab alone achieved PASI-100 [a 100% improvement in Psoriasis Area Severity Index score], or complete clearance, and about 40% of patients on the combined drugs achieved complete clearance at the primary end point
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