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In the same diet-induced obesity mouse model as our tirzepatide experiments, we observed comparable weight loss and other benefits when we administered azelaprag in combination with semaglutide, suggesting a class effect in incretins, as well as the potential for additivity with other appetite-suppressing weight loss therapies

Optical coherence tomography, or OCT, creates cross-sectional images of your retina, revealing swelling or fluid that might not be visible during a regular exam

Quick Answer: GLP-1 medications show clinically meaningful average weight loss in large-scale peer-reviewed trials - approximately 14.9% for semaglutide (STEP 1) and up to 20.9% for tirzepatide (SURMOUNT-1) under trial conditions

Participants had not reached a weight plateau, suggesting greater reductions might be observed with longer treatment