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The SMILES trial (Supporting the Modification of Lifestyle In Lowered Emotional States) was the first randomized controlled trial to investigate the efficacy of a 12-week dietary intervention in the treatment of major depressive disorder.23 Researchers designed a modified Mediterranean diet based on the Australian Dietary Guidelines and the Dietary Guidelines for Adults in Greece
Rushing to higher doses significantly increases the risk of both local and systemic side effects
10.1021/acsami.1c00583 46 LiY.WenG.LiJ.LiQ.ZhangH.TaoB.et al (2022)
doi: 10.1016/j.biomaterials.2024.122633 234 XingRZouQYuanCZhaoLChangRYanX
This combination activates two distinct GH-stimulating pathways simultaneously, producing synergistic pulsatile GH release that surpasses either compound in isolation
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