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The TMAO Cardiovascular Question The one substantive open debate concerns the same metabolic pathway
Other gastrointestinal effects Diarrhea, vomiting, abdominal pain, and excessive burping are additional gastrointestinal side effects reported in clinical trials
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47 Visceral fat accumulation in patients with obesity causes a number of changes (oxidative stress, activation of the RAAS and gut dysbiosis), resulting in insulin resistance, increased vascular stiffness, T2D, dyslipidaemia, hypertension, coronary atherosclerosis and, ultimately, HFpEF
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