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doi: 10.1073/pnas.1322098111 154 MishraPAmbsS
Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]
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The clinical relevance of these findings to humans remains unknown, and there is no evidence that acute overdose in humans increases thyroid cancer risk
GLP-1 receptors are present in several regions of the gastrointestinal (GI) tract, and their stimulation slows gastric emptying the rate at which food moves from the stomach into the small intestine
