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Shaking creates mechanical stress and shearing forces that can break the fragile peptide bonds, rendering it useless
Pan-coronavirus vaccine approaches Despite decades of research and multiple approaches being pursued, there are no protective vaccines for highly variable viruses such as HIV, influenza and HCV [126]
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Furthermore, how to combine these different antigens or epitope strings into a single vaccine is not a trivial question
The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A
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