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The demand for semaglutide and tirzepatide was so high that the FDA declared a shortage of them, which made it legal for generic drug companies and compounding pharmacies to prepare and distribute these drugs
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Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating
A key distinction between them is the scale of the compounded production: 503B allows outsourcing facilities to mass-produce compounded drugs, while 503A permits only patient-specific compounding of customized drugs for individual prescriptions
MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Strong appetite stimulation Mild cortisol elevation Mild prolactin elevation Flushing Injection-site reactions Known interactions Concurrent rhGH not recommended Glucocorticoids may blunt response Contraindications Active malignancy Pituitary tumor Pregnancy/lactation REGULATORY STATUS FDA Not FDA-approved
