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Dopamine is closely tied to the brains reward pathways and eating behavior, while norepinephrine can affect energy expenditure and fat metabolism
Cunningham theory revisited
Of those reporting no SGLT2i use at baseline, increasing numbers of participants started SGLT2i during the trial, with a greater proportion starting SGLT2i in the placebo (approximately 10% at 18 months and approximately 20% at 36 months) than in the semaglutide group (approximately 5% at 18 months and approximately 10% at 36 months
CNS Spectrums 2022;28(5):541560
Lancet 394 (10193), 131138
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