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The Lys residue at the 17th position was introduced at the C-terminus with an objective to modify its sidechain with a linker in the future (Supplementary Figure S2), so that the peptide can anchor to serum albumin similar to Semaglutide ( FIGURE 6 The first four residues of the N-terminus were also fixed for the following reasons
Unclear instructions Compounded medications can come with unclear instructions that are hard to follow
GLP-1s might act as a trigger, but they arent a full solution
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