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Tirzepatide is a newer synthetic peptide that binds two incretin receptors at once: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)
Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1
[PubMed ID: 29364588]
[27] was conducted specifically among patients who had undergone Roux-en-Y gastric bypass (RYGB)
In other words, at the end of 88 weeks, those who continued taking tirzepetide had lost on average 60 pounds, and those who went on the placebo maintained a 22-pound weight loss
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