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in Advances in Thomas Addison's Diseases (eds Bhatt, R., James, V

Because your body uses and excretes B12 rather than storing unlimited amounts, consistent timing helps keep your energy and focus steady instead of peaking and crashing. Many people find that taking B12 late in the day can make them feel more alert right when they are trying to wind down, which may interfere with sleep

[1] [3] Some medications, such as chloramphenicol, may interact with B12 therapy

But to ensure the accuracy of the information and the effectiveness of this vitamin for you, it is better to consult a dermatologist or nutritionist