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In the meantime, the drug will remain available to PBC patients under its accelerated approval status, according to Intercept

The N-capping box motif has been proposed to participate to the nucleation of helices as well as their folding and stabilization by forming reciprocal main chain-side chain hydrogen bonds between the N-cap (Ser/Thr) and the N3 (Glu/Asp) residues

When your body is under stress, its internal stores of glutathione can become depleted

Sturikova et al., 2018)