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Many reasons might explain this, like what you eat, how active you are, the dose youre on, and how your metabolism reacts

Super responders must prioritize high protein intake and resistance training to protect their metabolism. Nutrient Deficiencies: If the "fullness" signal is too strong, patients may struggle to eat enough calories to sustain basic organ function

Clinical trial data shows arthralgia incidence is generally similar to placebo, though some musculoskeletal symptoms appear in certain product summaries with varying frequency

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In 2023, tirzepatide under the name Zepbound was FDA-approved for obesity as well, after showing ~48 lbs (~22%) mean weight loss over 72 weeks in a trial (SURMOUNT-2) ( [137] )