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The plasmid system is relatively stable but has low cutting and editing efficiency, and continuous expression of Cas9 may increase off-target effects

Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinsons Disease

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(4) Notably, exposing wound models to the peptide has been linked with fewer infiltrating inflammatory cells and lower tissue levels of key inflammatory mediators such as leukotriene B4, thromboxane B2, and myeloperoxidase