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Results of the first phase 3 trial comparing orforglipron with oral semaglutide found that patients with diabetes lost on average 6-8% of their body weight with orforglipron, compared with 4-5% on semaglutide
Clinical data shows these symptoms happen because food takes too long to leave the stomach [10]
Compounded semaglutide is available by prescription only after medical evaluation, is not FDA-approved, and is not appropriate for everyone
That combination is expensive
For patients who find weekly semaglutide's prolonged nausea intolerable, this pharmacokinetic difference is clinically relevant
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