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Biomed Pharmacother 178:117174 Ma W, Hu J, Cheng Y, Wang J, Zhang X, Xu M (2015) Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of AktNrf2HO-1 signaling and reduction of NADPH oxidase

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PPP includes oxidative and non-oxidative phases, during which glucose 6-phosphate (G6P), the intermediate product in glycolysis, can be transformed into fructose-6-phosphate (F-6-P), glyceraldehyde-3-phosphate and ribose phosphate, and NADP + can be reduced to NADPH [44,45,46]

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Spatial multi-omics and metabolic flux analyzes may help elucidate this cross-compartmental dialog