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Proliferation phase: enhanced fibroblast migration and proliferation (40% increase per Chang et al.)

For the most stable conformation, observed at 85 and 86 ns, the residues ASP3 and ASP7 require the inclusion of calcium ions, along with ASP9 and LMG12, which may further stabilize the transition state to the structural conformation with the highest affinity for the membrane model

Its activity is inseparable from its copper cargo GHK is the delivery vehicle, Cu is much of the payload and together they act as a matrix-signaling molecule that rewires fibroblast behavior, angiogenesis, and gene expression toward a more youthful tissue profile

However, the resulting cryo-EM map from this sample only showed low-resolution features, indicating the structural flexibility of this complex