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These include transketolase-like 1 and 2 proteins, TKTL1 and TKTL2, as well as the ubiquitous (PDHA1) and testis-specific (PDHA2) isoenzymes of the -subunit of PDH (PDHA) (Figure 1B)

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The 2010/2011 American College of Rheumatology (ACR) criteria with the 2016 revision included the generalized pain criteria, defined as the presence of pain in 4 out of the 5 possible body regions, but there is still uncertainty and lack of accuracy in clinical practice

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More impressively, ARA-290 treatment initiated regrowth of small nerve fibers in the cornea, providing objective evidence of nerve regeneration that standard treatments simply cannot achieve