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This legislation firmly states that virtually all medicines administered by injection are automatically designated as Prescription-Only Medicines (POM), creating a powerful legal hurdle that cannot be overcome by simply demonstrating safety through clinical trials alone

[2] [11] As of 2026, retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it remains an experimental compound available only within authorised clinical trial settings

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Control mice, by comparison, gained 1.4% over the same period

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