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Utilizing targeted protein degradation (TPD) approach, we developed a GPX4-targeted AUTAC and demonstrated that GPX4-AUTAC promoted the ubiquitination of GPX4, and enhanced the binding with GPX4 and p62, leading to the selective autophagy-dependent degradation of GPX4

[25] [26] Micronutrient adequacy becomes more challenging with reduced food intake

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Additionally, methionine is a rate-limiting amino acid for protein synthesis and produces cysteine, a precursor to glutathione and taurine (2)