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Tamminga, C
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With regards to oxidant-driven differentiation of NSCs, exposure to the naphthoquinone derivate 1a resulted in an NRF2/SIRT1-dependent shift away from a neurogenic lineage towards a gliogenic fate, which was prevented by the addition of exogenous antioxidants (Santos et al., 2013)
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This is also why GHK-Cu appears frequently in longevity-adjacent research alongside other compounds studied for age-related cellular changes, since a quantifiable, age-correlated decline gives researchers a concrete variable to test against rather than a purely theoretical one
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