tirzepatide deadline nears for discounted weight loss drugs: What to know FDA Moves to Permanently Close

doi: 10.3389/fphar.2021.627533 Goldstein, A

Ozempic is used to improve glycemic control in people with type 2 diabetes

Safer Pain Management Options While on Tirzepatide Acetaminophen (Tylenol) is generally considered a safer first-line choice for mild to moderate pain when using tirzepatide

Tirzepatide is a once-weekly injection you administer at home

FDA-approved pharmacotherapy alternatives include several options with established safety profiles: Semaglutide (Wegovy): A GLP-1 receptor agonist producing 12-15% weight loss, with cardiovascular benefits demonstrated in the SELECT trial and FDA-approved indication for reducing cardiovascular risk Liraglutide (Saxenda): A GLP-1 receptor agonist producing 5-8% weight loss [4] Phentermine-topiramate (Qsymia): FDA-approved combination producing 7-10% weight loss with established safety data Naltrexone-bupropion (Contrave): Combination targeting reward pathways and appetite, producing 5-9% weight loss [4] Orlistat (Xenical, Alli): Lipase inhibitor producing 3-5% weight loss with gastrointestinal side effects [4] Setmelanotide (Imcivree): For rare genetic obesity disorders (POMC, PCSK1, LEPR deficiency) [4] Metabolic and bariatric surgery should be considered for patients with BMI 40 kg/m or 35 kg/m with obesity-related comorbidities who have not achieved adequate weight loss with nonsurgical interventions