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National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance

With approximately 80%90% of its fibers being afferent (from the gut to the brain), it transmits information about the state of the intestinal lumen, including the presence of microbial metabolites and cytokines, directly to brainstem nuclei, such as the nucleus of the solitary tract (NTS) (Bonaz et al., 2018)

[43] A small study showed that low serum ferritin was correlated with hypothyroid lab markers

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