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Individuals who are pregnant, breastfeeding, or have a history of pancreatitis, kidney failure, gallbladder disease, medullary thyroid carcinoma, MEN2 syndrome, or eating disorders should not use GLP-1 medications regardless of dose
Originally developed to manage diabetes, GLP-1 drugs like Ozempic and Wegovy (semaglutide) and Mounjaro and Zepbound (tirzepatide) are increasingly discussed online for uses beyond weight loss
The company is expected to file a NDA by the end of 2025 for the treatment of obesity
Both RAS and RAS-independent pathways can induce ferroptotic cell death (Yu et al., 2015)
Compared to newer GLP-1 drugs, dulaglutide tends to produce more moderate results
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