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The authors of the study identified two well-known side effects of semaglutide that likely led to DKA: appetite suppression and nausea
In clinical trials examining GLP-1 RA in combination with a sulphonylurea (with or without metformin) or insulin, the incidence of hypoglycemia was low overall, but increased when compared with placebo [114]
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The properties of the atom that holds the lone pair are important in determining both nucleophilicity and basicity
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